Yi-Wei Chang lab @ Penn

Welcome to the

CHANG LAB

 
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Research interests

Structure of macromolecules determines function. The Chang lab in the University of Pennsylvania is deeply interested in understanding the basis of biology from a structural perspective. Distinct from many other structural biology groups working with purified macromolecules, the Chang lab utilizes cryo-electron tomography (cryo-ET), a powerful cryo-electron microscopy imaging technique, to study the structure and mechanism of macromolecular machines directly inside cells. In the cellular context, cryo-ET reveals not only native conformations and assemblies of the macromolecular machines as they are conducting functions, but also their distribution, orientation and interaction with other cellular components – thus providing a unique opportunity to uncover structural mechanisms of complex cellular activities such as host-pathogen interactions.  

 
 
 
 
 
 
 

Cellular structural biology through cryo-electron tomography

 
 
 
 
 
 
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Dissect molecular structures in situ

 
 
 
 
 
 
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Host-pathogen interactions

 
 
 
 
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It is very easy to answer many ... fundamental biological questions; you just look at the thing!
— Richard Feynman (1959), "Plenty of Room at the Bottom"